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In a sentence
Rozdiel je značný.
The difference is substantial.
Naše názory sa značne líšia.
Our opinions differ considerably.
Značný počet ľudí prišiel na koncert.
A considerable number of people came to the concert.
Rozdiel v cene je značný.
The difference in price is significant.
Examples from Tatoeba (CC BY 2.0 FR).
Source
Slovak National Corpus (SNK) ↗English gloss from the frequency publish path. Includes Tatoeba example sentences when present.
Full attribution on References.